![]() ![]() Among 2400 goats, 31(1.29%) goats were not slaughtered because these goats showed severe clinical signs. Detail ante-mortem, and post-mortem (PM) lesions were inspected, and the suspected samples were collected aseptically from the lungs. Materials and methods: A total of 2400 goats that were slaughtered at the Hashim's Ethiopian Livestock and Meat Export abattoir, Ethiopia were randomly selected for this cross-sectional study during the period of October 2013 to July 2014. associated with pneumonic lungs showing respiratory signs of goats in Ethiopia. Objective: The objective of this study was to isolate and identify Pasteurella spp. It was concluded that the combination of tulathromycin and flunixin negatively altered the kinetics of tulathromycin. Significant decreases (39.8%) in the area under the curve (AUC) and (22.6%) in the elimination rate constant (Kel) from the central compartment were found following coadministration with flunixin compared with administration of tulathromycin alone. 5 (el)) were 1.35 and 1.8 h, for alone and combination groups, respectively. 5 (ab)were 0.54 and0.34 h and the elimination half-lives (t 0. Flunixin significantly altered the pharmacokinetics of tulathromycin by increasing its absorption and delay its elimination from body where t 0. 5) ab) of 0.54 h and the peak plasma concentration (C max) was 3.7ug/ml was attained after 0.98 h (T max). Tulathromycin was rapidly absorbed with a half-life of absorption (t(0. Serum concentrations of tulathromycin were determined using microbiological assay method. The animals were divided into two groups: the 1 st group was given tulathromycin alone and the 2 nd group was given tulathromycin concurrently with flunixin meglumine. The pharmacokinetic aspects of tulathromycin(2.5 mg/kg) administered alone and in combination with flunixin meglumine (2.2 mg/kg) after a single subcutaneous (SC) administration, werestudied in clinically healthy goats. ![]()
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